Agonist-induced desensitization of β-adrenergic receptors in rat myometrium
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منابع مشابه
Carbachol-induced desensitization of PLC-β pathway in rat myometrium: downregulation of Gqα/G11α.
In the estrogen-treated rat myometrium, carbachol increased the generation of inositol phosphates by stimulating the muscarinic receptor-Gq/G11-phospholipase C-β3 (PLC-β3) cascade. Exposure to carbachol resulted in a rapid and specific (homologous) attenuation of the subsequent muscarinic responses in terms of inositol phosphate production, PLC-β3 translocation to membrane, and contraction. Ref...
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In the present study, we investigated the possible mechanisms by which oxytocin might regulate oxytocin receptor (OTR) density. Exposure of cultured myometrial cells to oxytocin for a prolonged period caused desensitization: the steady-state level of oxytocin binding was 210 x 10(3) binding sites/cell, but this was time-dependently reduced to 20.1 x 10(3) sites/cell by exposing the cells to oxy...
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catecholamine-induced desensitization of adenylate cyclase in human neutrophils have been investigated as has the ability of hydrocortisone to modify such alterations. Incubation of human neutrophils with isoproterenol for 3 h in vitro resulted in an 86% reduction in the ability of isoproterenol to stimulate cyclic AMP accumulation in the cells. Two types of receptor alterations were documented...
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Pre-stimulation of Chinese hamster ovary (CHO) cells expressing the human m1-muscarinic receptor (CHO-m1 cells) with a maximally effective concentration of the muscarinic agonist methacholine resulted in desensitization of Ins(1,4,5)P3 accumulation, apparent as a approximately 4-fold shift in the agonist dose-response curve. Agonist-induced desensitization was rapid (detectable by 10 s) and con...
متن کاملCarbachol-induced desensitization of PLC-b pathway in rat myometrium: downregulation of Gqa/G11a
Lajat, Sandrine, Simone Harbon, and Zahra Tanfin. Carbachol-induced desensitization of PLC-b pathway in rat myometrium: downregulation of Gqa/G11a. Am. J. Physiol. 275 (Cell Physiol. 44): C636–C645, 1998.—In the estrogentreated rat myometrium, carbachol increased the generation of inositol phosphates by stimulating the muscarinic receptorGq/G11-phospholipase C-b3 (PLC-b3) cascade. Exposure to c...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1981
ISSN: 0014-5793
DOI: 10.1016/0014-5793(81)80937-4